Weisan Chen教授“医学免疫学基础”课程讲座更换上课地点通知

撰写时间:2017-08-22来源:华南农业大学

依托于兽医学院的我校丁颖讲座教授、澳大利亚华裔免疫学家、La Trobe大学生物化学系Weisan Chen教授将于今年8月下旬来我校举办为期5天的医学免疫学基础课程讲座。

讲座时间:2017826日至30日,每天上午8:30-11:00(包括授课及交流)

讲座地点:华南农业大学第一教学楼205 电教室(原通知地点为兽医学院新楼101

联系人:  陈建新 研究员,联系电话:13600066129

请已报名的老师及学生自行前往,8:25前到达教室


以下是讲座的详细介绍。


讲座提纲:

  1. Introduction and immune cell types

  2. Innate immunity

  3. Adaptive immunity: antibody structure and function

  4. Adaptive immunity: Major histocompatibility complex and Ag presentation

  5. Adaptive immunity: cellular immunity

  6. Immune diseases including viral, immune-genetic, autoimmune diseases


Weisan Chen 教授简历:

 Weisan Chen,陈卫三,1958年出生于湖南长沙,先后于1983年和1986年毕业于山西医科大学和湖南医科大学(中南大学湘雅医学),获医学学士及硕士学位;1994年获澳大利亚弗林德斯大学免疫学专业博士学位。1996-2000年在美国NIH进行博士后研究。2001-2012Ludwig Cancer Research Insitute T细胞实验室主任。现为澳大利La Trobe大学生物化学系免疫学教授,T细胞实验室主任。一直从事抗原递呈分子机理,肿瘤和流感病毒的细胞和分子免疫学研究。先后在Nature MedicineNature ImmunologyImmunity, J Exp MedGastroenterology, Gut, blood, PNAS, Cancer Res 等国际杂志发表研究论著130篇。曾获澳大利亚国家健康与医疗研究委员会CJ Martin学者金, 英国Wellcome高级研究员学者金及澳大利亚国家健康与医疗研究委员会高级研究员学者金。首次发现了第11种流感病毒基因编码产物PB1-F2并阐明其生物学功能,在免疫显性CD8+T细胞方面的研究成果卓著, 发现肿瘤细胞表达调节T细胞转录因子FOXP3

代表性研究成果:

1. Chen, W., McCluskey, J., Rodda, S. and Carbone, F.R. (1993) Changes at peptide residues buried in the MHC class I binding cleft influence T cell recognition: A possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J. Exp. Med. 177: 869-873.


2. Chen, W. Khilko, S; Fecondo, J; Margulies, D. H. and McCluskey, J. (1994) Determinant selection of MHC class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by non-dominant anchor residues.J. Exp. Med. 180: 1471-1483.


3. Chen, W; Jonathan W. Yewdell, Rodney L. Levine and Jack R. Bennink (1999) Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of MHC Class I-Restricted Viral Determinants.J. Exp. Med. 189: 1757-1764.


4. Chen, W, Luis C. Antón, Jack R. Bennink, Jonathan W. Yewdell. (2000) Dissecting the Multi-Factorial Causes of Immunodominance in Class I Restricted T Cell Responses to Viruses.Immunity. 12:83–93.


5. Weisan Chen, Christopher C. Norbury, Yunjung Cho, Jonathan W. Yewdell, and Jack R. Bennink.  (2001) Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral CD8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens.J. Exp. Med. 193: 1319-1326.


6. Weisan Chen*, Paul A. Calvo*, Daniela Malide, James Gibbs, Ulrich Schubert, Igor Bacik, Sameh Basta, Robert O’neill, Jeanne Schickli, Peter Palese, Peter Henklein, Jack R. Bennink & Jonathan W. Yewdell. (2001) A Novel Influenza A Virus Mitochondrial Protein That Induces Cell Death.Nature Medicine 7:1306-1312.


7. Davis ID*, Chen W*, Jackson H, Parente P, Shackleton M, Hopkins W, Chen Q, Dimopoulos N, Luke T, Murphy R, Scott AM, Maraskovsky E, McArthur G, MacGregor D, Sturrock S, Tai TY, Green S, Cuthbertson A, Maher D, Miloradovic L, Mitchell SV, Ritter G, Jungbluth AA, Chen YT, Gnjatic S, Hoffman EW, Old LJ, Cebon JS. (2004) Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans.PNAS101:10607~10702.

*Sharing first authorship indicated in the paper.


8. Weisan Chen, Ken Pang, Kelly-Anne Masterman, Gina Kennedy, Sameh Basta, Nektaria Dimopoulos, Felicita Hornung, Mark Smyth, Jack R. Bennink, and Jonathan W. Yewdell. (2004) Reversal in the Immunodominance Hierarchy in Secondary CD8+ T Cell Responses to Influenza A Virus: Roles for Cross-Presentation and Lysis-Independent Immunodomination The Journal of Immunology 173:5021-5027


9. Ebert, L.M., B. Tan, J. Browning, S. Svobodova, S.E. Russell, N. Kirkpatrick, C. Gedye, D. Moss, S. Ng, D. MacGregor, I.D. Davis, J. Cebon, and W. Chen*. (2008). The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res68(8):3001–9


10. Chao Wu, Damien Zanker, Bee Shin Tan, Sophie Valkenburg, Katherine Kedzierska, Quan Ming Zou, Peter C. Doherty, Weisan Chen*(2011). Systematically identify novel immunodominant CD8+ T cell responses to influenza A virus in healthy HLA-A2 individuals. PNAS, 108:9178-9183


简介链接:

All refs can be found:

https://scholar.google.com.au/citations?user=1XPXpDcAAAAJ&hl=en&oi=ao


Recent publications can be found on my lab website:

http://www.latrobe.edu.au/staff-profiles/show-profile-remote-content.php?uname=W3Chen


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