特邀学术报告 - 高分辨率单颗粒冷冻电镜及其在膜蛋白研究中的应用

发布者:群体微生物研究中心发布时间:2019-06-29浏览次数:445

特邀学术报告


时间:201973日下午330

地点:资环楼105室(芭田报告厅)

报告人:廖茂富教授

报告题目:高分辨率单颗粒冷冻电镜及其在膜蛋白研究中的应用

主持人:张炼辉教授

报告人简介

廖茂富教授1999年在清华大学获得生物学士学位,2006年在美国纽约爱因斯坦医学院获得生物医学科学博士学位,随后在国纽约爱因斯坦医学院和旧金山加州大学从事博士后工作,2014年入职哈佛医学院细胞生物学系任副教授,2018年起任教授。廖茂富教授主要从事微生物及真核膜蛋白结构的研究,在冷冻电镜结构生物学领域取得了突破性进展。近几年,以第一作者身份(或通讯作者身份)发表4Nature论文,Science研究论文2篇,2Cell论文,累计发表SCI论文24篇。

  

报告内容摘要

Cryo-electron microscopy (cryo-EM) is a rapidly advancing research area, and the technique of single-particle cryo-EM is a 'rising star' in structural biology, providing remarkably versatile and powerful tools to study the structure and function of biological macromolecules. Single-particle cryo-EM has achieved near-atomic resolution for biological samples ranging from large icosahedral viruses (~100 MDa) to small proteins (<100 kDa). Compared to more traditional methods such as X-ray crystallography and NMR spectroscopy, cryo-EM demonstrates a number of important advantages, such as small amount of sample required for EM analysis, flexibility in studying different functional states, and computational sorting of mixed conformations.

The Liao laboratory in the Department of Cell Biology at Harvard Medical School focuses on using single-particle cryo-EM to study membrane proteins. We are particularly interested to reveal the mechanisms of how proteins sense, move and convert specific lipid molecules. This will be achieved by obtaining high-resolution structures of lipid-interacting proteins, and by studying the dynamic protein conformations in native membrane environment.

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