2008年学术报告通知(18)

题目：Signal Transduction of Plant Steroid Hormones

演讲者：Li Jianming博士（University of Michigan）

时间：6月16日上午10时

地点：生命科学学院南楼211

Jianming Li

Associate Professor
Office Address: 4071B Nat. Sci.
Office Phone: (734) 763-4253
Email: jian@umich.edu

Li Lab Website
Lab Address: 4081, 4084, 4085 Nat. Sci.
Lab phone: (734) 615-0272

830 N. University
University of Michigan
LSA Molecular, Cellular, and Developmental Biology

Fields of Study

Molecular Genetics of Plant Steroid Signaling

Areas of Focus

Cell Biology
Development
Plant Molecular Biology

Research Interest

My lab is using Arabidopsis as a genetic model organism to investigate the molecular mechanism of plant steroid signaling.

About Jianming Li

Both animals and plants use steroids as signaling molecules to regulate a variety of growth and developmental processes, however, their signaling mechanisms are quite different. While animal steroids are mainly recognized by intracellular steroid receptors that provide a fast track for the chemical signals to move into the nucleus for controlling gene activities, plants steroids are perceived by a transmembrane receptor kinase that initiates a phosphorylation-mediated signal transduction pathway. For the last several years, my lab, along with several other plant steroid research groups, has identified several key regulators of the plant steroid signaling using Arabidopsis as our genetic model system. Currently, we are taking a combinatory approach of biochemistry, molecular biology, genetics, and chemical genetics to uncover additional components of the plant steroid signal transduction pathway and to study detailed biochemical mechanisms of each individual signaling components for transducing the steroid signal from the cell surface to the nucleus.

Publications

Peng, P., Yan, Z., Zhu, Y., & Li, J. (2008). "Regulation of the Arabidopsis GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 through proteasome-mediated protein degradation." Mol Plant 1(2): 338-346. PubMed Link

Jin, H., Yan, Z., Nam, K. H., & Li, J. (2007). "Allele-specific suppression of a defective brassinosteroid receptor reveals a physiological role of UGGT in ER quality control." Mol Cell 26(6): 821-830. PubMed Link

Li, J. & Jin, H. (2007). "Regulation of brassinosteroid signaling." Trends Plant Sci 12(1): 37-41. Epub 2006 Dec 4 PubMed Link

Li J (2005). "Brassinosteroid signaling: from receptor kinases to transcription factors." Curr Opin Plant Biol. 8: 526-531.

Cano-Delgado, A., Yin, Y., Cong, Y., Vafeados, D., Mora-Garcia, S., Cheng, J-C., Nam, K.H., Li, J.*, Chory, J.* (2004). "BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis." Development 131: 5341-5351. (*co-correspondence authors)

Nam, K.H., Li, J (2004). "The Arabidopsis Transthyretin-Like Protein Is a Potential Substrate of BRASSINOSTEROID-INSENSITIVE 1." Plant Cell 16: 2406-2017.

Li J (2003). "Brassinosteroids." Encyclopedia of Hormones. H. L. Henry & A. W. Norman, Academy Press, Boston

Peng P., Li J (2003). "Brassinosteroid signal transduction: a mix of conservation and novelty." J. Plant Growth Regulation 22: 298-312. (invited review)

Li J (2003). "Brassinosteroids signal through two receptor kinases." Curr. Opin. Plant Biol. 6: 494-499.

Dievart A, Dalal M, Tax FE, Huttly A, Li J. , Clark S (2003). "CLAVATA1 dominant-negative alleles reveal functional overlap between multiple receptor kinases that regulate meristem and organ development." Plant Cell 15: 1198-1211.

Zhao, J., Peng, P., Schmitz, R.J., Decker, A.D., Tax, F.E., Li, J (2002). "Two putative BIN2 substrates are nuclear components of brassinosteroid signaling." Plant Physiology 130: 1221-1229.

He, J.X., Gendron, J.M., Yang, Y., Li, J., Wang, Z.Y (2002). "The GSK3-like kinase BIN2 phosphorlates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis." Proc Natl Acad Sci USA 99: 10185-10190.

Nam, K.H., Li, J (2002). "BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling." Cell 110: 203-212.

Yin, Y., Wang, Z.Y., Mora-Garcia, S., Li, J., Yoshida, S., Asami, T., Chory, J (2002). "BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation." Cell 109: 181-191.

Li, J., Nam, K.H (2002). "Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase." Science 295: 1299-1301.

Li, J., Nam, K.H. Vafeados, D., Chory, D (2001). "BIN2, a new brassinosteroid-insensitive locus in Arabidopsis." Plant Physiology 127: 14-22.

Friedrichsen, D. M., Joazeiro, C.A.P., Li, J., Hunter, T., Chory, J (2000). "Brassinosteroid-Insensitive-1 Is a Ubiquitously Expressed Leucine-Rich Repeat Receptor Serine/Thereonine Kinase." Plant Physiology 123: 1247-1256.

He, Z., Wang, Z. Y., Li, J., Zhu, Q., Lamb, C., Ronald, P., Chory, J (2000). "Perception of Brassinosteroids by the extracellular domain of the receptor kinase BRI1." Science 288: 2360-2363.

Fujioka, S., J. Li, Y.-H.Choi, H. Seto, S. Takatsuto, T. Noguchi, T. Watanabe, H. Kuriyama, T. Yokota, J. Chory, A. Sakurai (1997). "The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis." Plant Cell 9: 1951-1962.

Li, J., J. Chory (1997). "A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction." Cell 90: 929-938.

Li, J., M.J. Biswas, A. Chao, D.W. Russel, J. Chory (1997). "Conservation of function between mammalian and plant steroid 5a-reductases." Proc. Natl. Acad. Sci. USA 94: 3554-3559.

Li, J., P. Nagpal, V. Vitart, T.C. McMorris, J. Chory (1996). "A role for brassinosteroids in light-dependent development of Arabidopsis." Science 272: 398-401.

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